Hyperborée. Fragments de cosmographie grecque

Fragments de l'arithmétique dans une combinaison de procédures de décision. (Fragments of arithmetic in a combination of decision procedures)

LRFragLib: an effective algorithm to identify fragments for de novo protein structure prediction

Motivation The quality of fragment library determines the efficiency of fragment assembly, an approach that is widely used in most de novo protein-structure prediction algorithms. Conventional fragment libraries are constructed mainly based on the identities of amino acids, sometimes facilitated by predicted information including dihedral angles and secondary structures. However, it remains cha...

Enhancement of reporter gene de novo methylation by DNA fragments from the alpha-fetoprotein control region.

The 5'-upstream region of the rat alpha-fetoprotein (AFP) gene strongly increased de novo methylation of an adjacent chloramphenicol acetyltransferase (CAT) gene upon transfection into F9 mouse embryonal carcinoma cells. The same effect was exerted by a distal 775-base pair (bp) fragment and by 300- and 1-kb fragments preceding the transcriptional start site, but not by other parts of the contr...

De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

Protein kinases constitute an attractive family of enzyme targets with high relevance to cell and disease biology. Small molecule inhibitors are powerful tools to dissect and elucidate the function of kinases in chemical biology research and to serve as potential starting points for drug discovery. However, the discovery and development of novel inhibitors remains challenging. Here, we describe...

La mise-à-jour des croyances pour des fragments de la logique propositionnelle

Recently, belief change within the framework of fragments of propositional logic has gained attention. Previous works focused on belief contraction and belief revision mainly on the Horn fragment. However, the problem of belief update within the framework of fragments of propositional logic has been neglected so far. This paper presents a general approach to define new update operators derived ...